Skill Checkup: A Woman With Increasing Abdominal Pain, Nausea, Vomiting, and Ascites

Pamela Soliman, MD, MPH


April 21, 2022

Endometrial cancer is the most common gynecologic malignancy in the United States, with an estimated 2.8% of women who will be diagnosed at some point in their lifetime. The incidence of endometrial cancer is rising with increased life expectancy and obesity. The mortality rate for uterine cancer also appears to be increasing more rapidly than the incidence rate, a trend which may be related to the identification of more advanced-stage cancers, high-risk histologies, such as serous carcinomas, and patients being diagnosed at an older age. The mortality rate is greatly affected by high-grade carcinomas that are more likely to present at an advanced stage and have a higher likelihood of recurrence.

In patients with uterine serous carcinoma, such as the patient in this case, adjuvant platinum/taxane-based therapy appears to improve survival. Of note, allergic reactions are more common with platinum agents.


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