Fast Five Quiz: Advanced and Metastatic Gastric Cancer

Elwyn C. Cabebe, MD


April 06, 2022

Jaundice is a late complication of gastric cancer, pointing to metastatic disease, according to Cabebe and colleagues. Intrahepatic jaundice is often owing to hepatomegaly, a direct result of tumor spread to the liver. Extrahepatic jaundice is one of the more common causes of malignant biliary obstruction by metastatic cancer. Bile duct obstruction in advanced gastric cancer is predominantly owing to metastatic lymphadenopathy in the hepatoduodenal ligament around the level of the cystic duct.

Early gastric cancer has no associated symptoms; however, some patients with incidental complaints, such as dysphagia, nausea, and indigestion, are diagnosed early. Most symptoms of gastric cancer reflect advanced disease.

Learn more about the clinical presentation of gastric cancer.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.