Because of lower toxicity, two-drug cytotoxic regimens (eg, fluoropyrimidine and oxaliplatin) are preferred for patients with advanced disease.
Perioperative chemotherapy (eg, FLOT), or postoperative chemotherapy plus chemoradiation (fluorouracil [5-FU] or capecitabine + oxaliplatin plus infusional fluoropyrimidine), is preferred for localized gastric cancer.
Two-drug regimens are preferred because of lower toxicity. Three-drug regimens should be reserved for patients who are medically fit and have access to frequent follow-up. Oxaliplatin is generally preferred over cisplatin owing to lower toxicity.
Learn more about gastric cancer treatment.
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Cite this: Elwyn C. Cabebe. Fast Five Quiz: Advanced and Metastatic Gastric Cancer - Medscape - Apr 06, 2022.