According to the ESMO guidelines, pre- and postoperative chemotherapy with a platinum and fluoropyrimidine combination is recommended for patients with stage IB or higher resectable gastric cancer; capecitabine-containing regimens can also be suggested.
Second-line chemotherapy options include irinotecan and docetaxel or paclitaxel.
In HER2-positive disease, recommended chemotherapy is with trastuzumab plus cisplatin and either 5-fluorouracil or capecitabine.
In HER2-negative disease, combination regimens on the basis of a platinum-fluoropyrimidine doublet are generally used; triplet regimens are controversial, but the addition of an anthracycline (eg, epirubicin) has demonstrated benefit.
Learn more about gastric cancer treatment guidelines.
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Cite this: Elwyn C. Cabebe. Fast Five Quiz: Gastric Cancer Management - Medscape - Apr 06, 2022.