Rapid Rx Quiz: Myasthenia Gravis Treatments

Mary L. Windle, PharmD

Disclosures

March 15, 2022

Other than hirsutism, adverse effects of prednisone include:

  • Metabolic changes: negative nitrogen balance due to protein catabolism

  • Cardiovascular changes: hypertension, bradycardia, cardiac arrhythmias, cardiac enlargement, congestive heart failure, fat embolism, myocardial rupture after recent myocardial infarction, pulmonary edema, tachycardia, thromboembolism, and vasculitis

  • Endocrine changes: decreased carbohydrate tolerance, abnormal fat deposits, development of cushingoid state, manifestations of latent diabetes, moon face, and secondary adrenocortical and pituitary unresponsiveness

  • Dermatologic changes: acne, cutaneous and subcutaneous atrophy, dry scalp, edema, impaired wound healing, rash, striae, thin fragile skin, thinning hair on the scalp, and urticaria

  • Fluid and electrolyte disturbances: hypertension, fluid retention, hypokalemic alkalosis, potassium loss, and sodium retention

  • Gastrointestinal issues: abdominal distention, elevated serum liver enzymes levels, hiccups, nausea, pancreatitis, ulcer, and ulcerative esophagitis

  • Musculoskeletal issues: Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteonecrosis of femoral and humeral heads, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, and vertebral compression fractures

  • Neurologic symptoms: convulsions, emotional instability, headache, insomnia, meningitis, mood swings, neuropathy, paresthesia, personality changes, and vertigo

  • Ophthalmic changes: central serous chorioretinopathy, glaucoma, exophthalmos, increased intraocular pressure, and posterior subcapsular cataracts

  • Reproductive signs: alteration in sperm count and motility

Learn more about prednisone.

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