Hyperglycemia and metabolic dysfunction associated with type 2 diabetes increase the level of oxidative stress, impairing the endothelium. Thus, the earliest vascular abnormality seen in patients with type 2 diabetes is endothelial dysfunction, which initiates a series of inflammatory responses: vasoconstriction of blood vessels, platelet aggregation, and inhibition of anticlotting systems. The resulting prothrombic state promotes thrombus formation leading to atherosclerotic changes and narrowing of blood vessels responsible for the development of macrovascular complications in patients with type 2 diabetes.
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Cite this: Romesh Khardori. Fast Five Quiz: Type 2 Diabetes and Cerebrovascular Disease - Medscape - Apr 27, 2022.