Rapid Review: Sepsis

Richard H. Sinert, DO


April 08, 2022

In a recent multicenter cohort study of patients with sepsis, 19.8% presented with septic shock and 25.5% died. Among patients who received antibiotics within 3 hours, for every 1-hour delay in antibiotic administration, those with septic shock had a 35% (P = .042) increased risk for mortality. Researchers observed no such trend in patients without shock. For all patients together whose time-to-antibiotics was within 1 hour, adjusted odds ratio (OR) for in-hospital mortality was 0.78 (95% CI, 0.61-0.99; P = .046). In patients with septic shock, the adjusted OR for in-hospital mortality was statistically significant at 0.66 (95% CI, 0.44-0.99; P = .049), whereas in patients with sepsis but without shock, it was 0.85 (95% CI, 0.64-1.15; P = .300).

Learn more about septic shock.


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