Not all biologics are the same, and the newer biologics tend to be more effective and tolerable and may act more rapidly. These may include interleukin (IL)-17 inhibitors (such as brodalumab or ixekizumab) and the IL-23 inhibitors such as guselkumab or tildrakizumab. Brodalumab has been associated with rare cases of suicidal ideation and completed suicide and so should not be taken by this patient, who reports being depressed.
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Cite this: David T. Robles. Skill Checkup: A 32-Year-Old Man With an Acute Flare of Psoriasis - Medscape - May 11, 2022.