Rapid Rx Quiz: Anticonvulsants

Mary L. Windle, PharmD


April 15, 2022

A Swedish cohort study reviewed individual-level data on all adults with acute stroke from July 1, 2005, to December 31, 2010, and subsequent onset of epilepsy before December 31, 2014. Data for 2577 eligible patients receiving continuous antiseizure medication monotherapy were analyzed between 2019 and 2021. All-cause death, the primary outcome, was analyzed using Cox proportional hazards regression with carbamazepine as the reference.

Compared with carbamazepine, the adjusted hazard ratios of all-cause death were:

  • 0.72 (95% CI, 0.60-0.86) for lamotrigine

  • 1.40 (95% CI, 1.23-1.59) for valproic acid

  • 1.16 (95% CI, 0.88-1.51) for phenytoin

  • 1.16 (95% CI, 0.81-1.66) for oxcarbazepine

Learn more about lamotrigine.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.