Rapid Rx Quiz: Anticonvulsants

A Swedish cohort study reviewed individual-level data on all adults with acute stroke from July 1, 2005, to December 31, 2010, and subsequent onset of epilepsy before December 31, 2014. Data for 2577 eligible patients receiving continuous antiseizure medication monotherapy were analyzed between 2019 and 2021. All-cause death, the primary outcome, was analyzed using Cox proportional hazards regression with carbamazepine as the reference.

Compared with carbamazepine, the adjusted hazard ratios of all-cause death were:

• 0.72 (95% CI, 0.60-0.86) for lamotrigine

• 1.40 (95% CI, 1.23-1.59) for valproic acid

• 1.16 (95% CI, 0.88-1.51) for phenytoin

• 1.16 (95% CI, 0.81-1.66) for oxcarbazepine

Learn more about lamotrigine.

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Cite this: Mary L. Windle. Rapid Rx Quiz: Anticonvulsants - Medscape - Apr 15, 2022.