Rapid Rx Quiz: Anticonvulsants

Mary L. Windle, PharmD


April 15, 2022

The meta-analysis found that, of all the available overweight and obesity medications, phentermine-topiramate was the most effective for weight loss (odds ratio [OR] of ≥ 5% weight reduction, 8.02 [95% CI, 5.24-12.27]; mean difference [MD] of percentage bodyweight change, −7.97 [95% CI, −9.28 to −6.66]). Glucagon-like peptide 1 (GLP-1) receptor agonists were next in effectiveness (OR, 6.33 [95% CI, 5 to 8]; MD, −5.76 [95% CI, −6.30 to −5.21]). All drugs except levocarnitine lowered body weight somewhat compared with lifestyle modification alone. However, increased adverse events leading to drug discontinuation were associated with naltrexone-bupropion, phentermine-topiramate, GLP-1 receptor agonists, and orlistat.

Learn more about phentermine/topiramate.


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