Rapid Review Quiz: Mental Health Comorbidities

Stephen Soreff, MD


April 22, 2022

A recent Mendelian randomization study investigated the association between allergic disease and mental health. Researchers found strong evidence of phenotypic associations between all mental health and personality phenotypes investigated (except schizophrenia), replicating earlier findings. The results suggest that the observed clinical comorbidity between mental health problems and allergic disease is unlikely to be causal. Although interventions designed to prevent allergic disease are unlikely to directly improve mental health and vice versa, some evidence suggests that effectively treating skin disease can improve mental well-being.

The study also identified associations with specific allergic diseases (atopic dermatitis, asthma, and hayfever). Associations between AD and hayfever with bipolar disorder were weaker.

Learn more about allergic diseases.


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