Rapid Rx Quiz: Diabetes Drugs

Mary L. Windle, PharmD


May 13, 2022

Patients taking semaglutide at 0.5 mg/wk subcutaneously (SC) should transition to 7 mg or 14 mg orally starting up to 7 days after their last injection. The initial dose of oral semaglutide is 3 mg/d for 30 days. The 3-mg dose is intended for treatment initiation and is not effective for glycemic control. After 30 days on 7 mg/d, patients may increase dose to 14 mg/d if additional glycemic control is needed; however, taking two 7-mg tablets to achieve 14 mg dose is not recommended. Oral semaglutide is not recommended as a first-line therapy for patients who have inadequate glycemic control on diet and exercise.

Learn more about semaglutide.


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