Obesity has consistently been established as a modifiable risk factor for the development of knee OA. Increased mechanical stress and sedentary lifestyles associated with obesity may contribute to higher susceptibility to knee damage owing to joint instability and weakness. A study by Jin and colleagues had shown that obese individuals have a 4.6 times greater risk of developing OA compared with healthy-weight individuals. In addition, weight loss may prevent further degeneration and reduce the risk for future complication, such as total knee replacement.
Although less prevalent, other modifiable risk factors for the knee OA include physically demanding occupations that require heavy lifting and bending, previous joint trauma or surgery, and hypertension.
Smoking has not been established as a risk factor for the development of knee OA, per Kong and colleagues.
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Cite this: James Monroe Laborde. Fast Five Quiz: Knee Osteoarthritis Presentation and Diagnosis - Medscape - May 18, 2022.