Fast Five Quiz: Intra-articular Injections for Knee Osteoarthritis

James Monroe Laborde, MD, MS


May 18, 2022

The most common side effects of intra-articular knee injections are pain and bleeding at the injection site. Some patients may complain of symptom exacerbation, followed by improvement in pain within the first 48 hours. A rare complication of intra-articular injections is septic arthritis, mostly caused by Staphylococcus aureus. Risk factors for septic arthritis include prior joint surgery, immunosuppressive medication, and diabetes.

Tendon rupture and nerve damage are complications associated with joint injections; however, they are uncommon with knee injections.

Learn more about the management of knee OA.


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