Fast Five Quiz: Intra-articular Injections for Knee Osteoarthritis

James Monroe Laborde, MD, MS


May 18, 2022

IACS injections are frequently performed to treat knee OA in patients with significant pain that has not responded to weight loss, exercise, and oral medications. IACS may be effective for short-term management of knee OA pain, particularly with acute flare-ups and inflammation. IACS injections, on average, significantly reduce OA knee pain for 4-6 weeks. However, evidence is conflicting regarding the benefits. Research has suggested that IACS injections may lead to accelerated OA progression, subchondral insufficiency fractures, osteonecrosis, and rapid joint destruction. While the American College of Rheumatology recommends IACS injections owing to good short-term outcomes for knee OA, clinical practice guidelines by the American Academy of Orthopedic Surgeons do not support conclusive recommendations for IACS injections.

Learn more about the management of knee OA.


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