Fast Five Quiz: Intra-articular Injections for Knee Osteoarthritis

James Monroe Laborde, MD, MS


May 18, 2022

A vast number of studies have evaluated the potential use of mesenchymal stem cells for the treatment of OA. Preclinical and clinical trials have reported effective alleviation of pain and improvement of function in patients with knee OA. In 2021, results from the phase 1/2a US Food and Drug Administration-approved clinical trials using mesenchymal stem cells from adipose tissue were promising.

Strategies involving the use of gene editing for the treatment of OA have been proposed; however, no compounds are currently under investigation.

Analyses have suggested that botulinum toxin type A is an effective and safe treatment option for pain owing to knee OA. However, additional clinical trials are needed to determine efficacy and safety.

Learn more about the management of knee OA.

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