A recent meta-analysis of the epidemiologic evidence for an association between cobalt exposure and carcinogenicity based on studies of cobalt exposure via either TJR or occupational exposure examined 27 cancer sites. Of those, only two anatomic sites had greater estimates; however, stratified analyses to evaluate biases found no consistent increase by follow-up period, exposure type, or measure of association. This suggests other potential explanations, including confounding bias in detection and reporting. The current evidence is insufficient to conclude an increased risk for site-specific cancers associated with TJR.
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Cite this: Elwyn C. Cabebe. Rapid Review Quiz: Carcinogens - Medscape - May 16, 2022.