Fast Five Quiz: Early Non–Small Cell Lung Cancer

Daniel S. Schwartz, MD

Disclosures

May 24, 2022

Current NCCN guidelines advise that all patients with adenocarcinoma NSCLC have DNA mutational analysis EGFR mutations. EGFR is a growth factor receptor that induces cell differentiation and proliferation upon activation. Therefore, mutations of this receptor are significant because the use of EGFR tyrosine kinase inhibitors, such as osimertinib, is a viable first-line adjuvant treatment.

Thus, in addition to immunohistochemical analyses to identify tumor type and lineage, it is essential to conserve tissue for molecular testing.

Learn more about workup of NSCLC.

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