Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)

B.S. Anand, MD


May 27, 2022

Liver biopsy remains the criterion standard for diagnosis of NASH, although the procedure is costly and carries increased risk for complications. Measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) may not be as useful for diagnosing NAFLD and NASH due to poor specificity and sensitivity; in patients with NASH, AST and ALT levels can be in the normal range. FibroScan is underutilized but is useful for disease staging and longitudinal monitoring. However, it is not as useful for diagnosis. Routine liver ultrasound may reveal hepatic steatosis but cannot rule out hepatic steatosis or show the extent of steatosis.

Learn more about liver biopsy and histopathologic examination for NAFLD.


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