Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)

B.S. Anand, MD


May 27, 2022

In a recent systematic review and meta-analysis, Fernández and colleagues observed that lifestyle changes are effective treatment for NAFLD and that combined diet and exercise interventions are superior to either intervention alone. Specifically, combined diet and exercise interventions produced greater reductions in ALT (mean difference [MD], -13.27; 95% CI, -21.39 to -5.16), AST (MD, -7.02; 95% CI, -11.26 to -2.78), and homeostatic model assessment for insulin resistance (HOMA-IR) (MD, -2.07; 95% CI, -2.61, -1.46) than either exercise alone (HOMA-IR, AST, and ALT nonsignificant; MD, -0.46; 95% CI, -0.8 to -0.12) or diet alone (ALT MD, -4.48; 95% CI, -1.01 to -0.21; HOMA-IR MD, -0.61; 95% CI, -1.01 to -0.21). The team found that exercise improved quality of life (MD, -2.64; 95% CI, -5.18 to -0.09), but exercise alone was not as effective as when combined with dietary interventions.

Learn more about treatment and management of NAFLD.


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