Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)

B.S. Anand, MD


May 27, 2022

In a recent cross-sectional study, irregular or long menstrual cycles were associated with increased NAFLD incidence and prevalence risk in young, premenopausal women. Of 72,092 women, 36,378 (27.7%) had menstrual cycles of 26-30 days and were identified as the index group. The prevalence of NAFLD in this group was 5.8%. For those with a menstrual cycle of 31-39 days, the prevalence rate climbed to 7.2%. For those with a menstrual cycle of at least 40 days or too irregular to estimate, the prevalence was 9.7%. The prevalence was 7.1% for those with a menstrual cycle less than 21 days.

Although the mechanism is unclear, estrogen exposure appears to be the factor connecting NAFLD and longer, more irregular periods. The researchers concluded that women with irregular or long menstrual cycles may benefit from advice concerning lifestyle modification and risk reduction for NAFLD and related cardiometabolic diseases.

Learn more about the epidemiology of NAFLD.

This Rapid Review Quiz was excerpted and adapted from the Medscape articles AHA issues First Scientific Statement on NAFLD and CVD, Irregular and Long Periods Linked to NAFLD, Fatty Liver, Estrogen Therapy, Weekend Catch-up Sleep May Help Fatty Liver, and Antihyperglycemic Drugs Likely Effective for NAFLD.

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