Rapid Review Quiz: Mindfulness

Stephen Soreff, MD


June 06, 2022

In a randomized controlled study, Garland and colleagues compared MORE with supportive psychotherapy alone in patients with chronic pain and opioid misuse. A total of 129 patients were randomly assigned to the MORE group, which provided the patients with sequenced training in mindfulness, savoring, and reappraisal skills. A total of 121 patients were randomly assigned to the supportive psychotherapy group and received eight 2-hour weekly sessions.

Garland and colleagues found that the MORE group was about twice as likely to reduce opioid misuse through 9 months of follow-up compared with the supportive psychotherapy group (odds ratio [OR], 2.06; 95% CI, 1.17-3.61; P = .01). In reducing opioid misuse by 45% after 9 months of treatment, MORE exceeded the effect size of other opioid misuse therapies among people with chronic pain and better than doubled the effect of standard supportive psychotherapy. MORE was also found to be superior to supportive psychotherapy for pain severity through 9 months of follow-up (between-group effect, 0.49; 95% CI, 0.17-0.81; P = .003) and pain-related functional interference (between-group effect, 1.07; 95% CI, 0.64-1.50; P < .001).

Learn more about opioid abuse and its treatment.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.