Fast Five Quiz: Juvenile Hypophosphatasia Management

Eric T. Rush, MD, FAAP, FACMG


July 22, 2022

Hypophosphatasia (HPP) is a rare inherited disease caused by mutations in the ALPL gene. The ALPL gene is responsible for the production of the enzyme called tissue nonspecific alkaline phosphatase, which is essential for the proper mineralization of bones and teeth. Childhood HPP can be inherited in an autosomal dominant or autosomal recessive manner, resulting in a wide range of clinical variability. Although patients with childhood HPP typically lack life-threatening symptoms, they may still have significant disease, with chronic manifestations. Because of the systemic presentation, the management requires a multidisciplinary approach to improve morbidity for patients with juvenile HPP.

How much do you know about juvenile management of HPP? Test your knowledge with this quick quiz.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.