Rapid Review Quiz: New Diagnostic Tests

Elwyn C. Cabebe, MD; Herbert S. Diamond, MD; Michael Stuart Bronze, MD; Helmi L. Lutsep, MD

Disclosures

June 13, 2022

The proposed test detects antiphospholipid antibodies in the serum of patients with Lyme disease. Further development will be required to establish the specificity of the test in clinical settings. The test is not yet ready for clinical use and should not currently be used for patient care.

Thus far, by testing for elevated antiphospholipid antibodies, researchers were able to detect infection earlier and with improved sensitivity compared with current tests. Patient sera demonstrated declining antiphospholipid titers after therapy. Although differences in bacterial strains can affect protein serology generally, they are not relevant here because the test detects responses to a host lipid. Because these autoantibodies to lipids appear to arise and disappear more quickly compared with traditional tests, with further development, this antibody response may become a useful adjunctive test when added to current Lyme diagnostics both for identifying reinfection and for following clearance of infection after treatment.

Learn more about Lyme disease and tick-borne illnesses.

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