Fast Five Quiz: SARS-CoV-2 Variants Associated With COVID-19

Glenn Wortmann, MD; Antonio Di Biagio, MD


October 02, 2023

As of September 2023, a new variant of SARS-CoV-2 rapidly increased in prevalence around the world to become the most dominant variant globally: EG.5 (Eris). A descendent lineage of XBB.1.9.2, EG.5 and sublineages of EG.5 (EG.5.1, EG.5.1.1 and EG.5.2) share the spike amino acid profile with XBB.1.5 (Kraken). Compared with these parent subvariants, EG.5 also has an additional F456L amino acid mutation in the spike protein (the subvariant EG.5.1 has another spike mutation, Q52H).

Prior, the WHO designated EG.5 and its sublineages as variants of interest on 8 August 2023.

Learn more about the EG.5 variant.


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