Fast Five Quiz: Narcissistic Personality Disorder Key Aspects

Stephen Soreff, MD


June 24, 2022

Patients with NPD often benefit from the use of medications to treat symptoms associated with the disorder or to manage comorbid axis I diagnoses, including bipolar disorder, major depressive disorder, and dysthymia. These drugs include antipsychotics, antidepressants (selective serotonin reuptake inhibitors [SSRIs]) in particular, and mood stabilizers. Escitalopram is among the SSRIs that may be used to manage comorbid mental health concerns in adults with NPD. SSRIs are the antidepressants of choice in these patients because of their minimal anticholinergic effects.

Propranolol and lorazepam are sometimes used off-label to treat anxiety. However, they are not among the commonly used medications for patients with NPD who have comorbid axis I diagnoses. Phenelzine is a monoamine oxidase inhibitor, a class of antidepressants not commonly used in patients with NPD.

Learn more about medications for NPD.


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