Fast Five Quiz: Obesity-Related Hypertension

Michael Weber, MD


August 09, 2022

According to Khalil and colleagues, ACE inhibitors, ARBs, and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes who are obese.

Alpha blockers are not indicated for first-line therapy use, per Alexander and colleagues. They can be combined with any other class of drugs used to treat hypertension to create combination therapy options.

Renin inhibitors have an additive effect when used with diuretics and is indicated for hypertension as monotherapy or in combination with other antihypertensive drugs. This class of drugs is still under investigation and should be avoided during pregnancy. Aliskiren can cause adverse events when used in combination with ACE inhibitor or ARB therapy, and such combinations should never be used.

Learn more about guidelines for the management of obesity.


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