TTR V122I originated in West Africa and is more common in those of African ancestry. In 1997, it was reported that TTR V1221 was carried by 3.9% of African Americans in the United States and ≥ 5% of the population in some areas of West Africa.
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Cite this: Marco Luigetti. Skill Checkup: A 68-Year-Old Man With Acute Decompensated Heart Failure, Worsening Dyspnoea and Lower Extremity Oedema - Medscape - Aug 18, 2022.