Skill Checkup: A 53-Year-Old Woman With Dry Cough and a Lung Lesion

John C. Leighton Jr, MD, FACP


September 01, 2022

RET rearrangements in non–small cell lung cancer (NSCLC) appear to be associated with a high risk for brain metastases. They occur in approximately 25% of patients with RET-positive NSCLC, although in the ARROW trial, approximately 50% of the patients with RET-altered NSCLC were found to have developed brain metastases. In the LIBRETTO-01 study, 36% of patients had brain metastases. The lifetime prevalence of brain metastasis in stage IV NSCLC has been reported to be 46%.


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