Fast Five Quiz: Pharmacologic Therapy for Major Depressive Disorder

Claudia L. Reardon, MD


August 26, 2022

Major depressive disorder is one of the most common mood disorders among the general adult population and imparts the heaviest burden of disability among psychologic disorders. Globally, women are approximately twice as likely to experience depression as men.

Among the criteria for major depressive disorder, the onset of five or more of the following symptoms, as indicated by subjective report or observation by others, must be present nearly every day during the same 2-week period: depressed mood most of the day; markedly diminished interest or pleasure in all, or almost all, activities most of the day; significant weight loss when not dieting or weight or change in appetite; insomnia or hypersomnia; psychomotor agitation or retardation; fatigue or loss of energy; feelings of worthlessness or excessive or inappropriate guilt (which may be delusional); diminished ability to think or concentrate or indecisiveness; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

A wide range of treatment approaches and guidelines are available for major depressive disorder, including medication, psychotherapy (eg, cognitive behavioral therapy [CBT] or interpersonal therapy), and a combination of these modalities.

Are you up to date with pharmacologic therapy for major depressive order? Test your knowledge with this quick quiz.


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