Fast Five Quiz: Pharmacologic Therapy for Major Depressive Disorder

Claudia L. Reardon, MD


August 26, 2022

According to the 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders, the goal of treatment in the acute phase of major depressive disorder should be to achieve functional recovery.

For the initial treatment of adults with major depressive disorder, either psychotherapy or second-generation antidepressants are recommended, per Ross and colleagues. Different models of psychotherapy include behavioral therapy, cognitive and CBT, interpersonal psychotherapy, psychodynamic therapy, and supportive therapy. For a combined treatment approach, CBT or interpersonal psychotherapy plus a second-generation antidepressant is recommended.

Learn more about the treatment for depression.


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