Rapid Review Quiz: Vitamin D

Romesh Khardori, MD


September 06, 2022

Two recent meta-analyses considered vitamin D supplementation and IBS. The first included four randomized, placebo-controlled trials involving 335 participants. The researchers assessed vitamin D efficacy in IBS with outcomes before and after supplementation using the irritable bowel syndrome severity scoring system (IBS-SSS), IBS-QoL, and IBS-TS.

IBS-SSS score in the intervention group showed greater improvement after vitamin D supplementation compared with the placebo group (which the second team did not find, see below). Participants receiving vitamin D also showed IBS-QoL improvement. The researchers did not evaluate the efficacy of vitamin D intervention in IBS-TS for sensitivity reasons.

The second systematic review and meta-analysis included six randomized controlled trials with 616 patients assessing vitamin D efficacy in IBS. IBS-SSS was the primary outcome and IBS-QoL and serum level of calcifediol 25(OH)D were the secondary outcomes; this team did not consider IBS-TS.

The team found no difference between vitamin D and placebo in IBS-SSS scores, unlike the first analysis. The IBS-Qol and serum 25(OH)D scores were both favored in the pooled analysis for vitamin D over placebo.

Learn more about IBS.


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