Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by a three-phase clinical course comprising an initial chronic phase, an accelerated phase, and a blast phase. Most cases of CML are diagnosed in the chronic phase, during which patients may be asymptomatic or may display signs and symptoms, such as fatigue, low-grade fever, elevated white blood cell count or splenomegaly, early satiety, left upper quadrant abdominal pain from spleen infarction, and/or hepatomegaly. Once the disease has entered the accelerated phase, bleeding, petechiae, and ecchymoses may be present. Bone pain, fever, worsening anemia, thrombocytopenia, basophilia, and a rapidly enlarging spleen are typically seen during a blast crisis.
CML accounts for approximately 20% of all leukemias affecting adults. In the last decade, advances in the management of CML have transformed the field, leading to improved outcomes and new treatment goals for patients.
How familiar are you with the management of CML? Test your knowledge with this quick quiz.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Chronic Myelogenous Leukemia Management - Medscape - Sep 21, 2022.