Before insulin was discovered, scientists hypothesized that the pancreas controlled carbohydrate metabolism by secreting some substance. An orthopedic surgeon, Frederick Banting, "had the idea of isolating pancreatic islet extracts by ligating the pancreatic duct of dogs, keeping them alive until the acini degenerated, leaving the islets for isolation." His experiments at the University of Toronto in 1921 eventually led to the development of insulin for human use; the first such injection was on January 11, 1922.
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Cite this: Medscape Staff. Trivia Quiz: Major Medical Milestones - Medscape - Sep 26, 2022.