Ascanio Sobrero discovered nitroglycerine in 1847, noting a "violent headache" produced by tiny quantities used on the tongue. It was first used as a powerful vasodilator during the mid-19th century. It was used for angina by the likes of William Murrell and Thomas Lauder Brunton, the father of modern pharmacology, in the 1800s. Eventually, William Martindale included 1/100th of a grain of nitroglycerine in chocolate.
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Cite this: Medscape Staff. Trivia Quiz: Major Medical Milestones - Medscape - Sep 26, 2022.