Skill Checkup: A 70-Year-Old Man With Loss of Smell, Dry Cough, and Headache

Enrico Brunetti, MD


November 07, 2022

While the patient is taking nirmatrelvir/ritonavir for COVID-19, he may continue saxagliptin therapy with a dose reduction to 2.5 mg daily. Other diabetes medications, such as empagliflozin, insulin, metformin, and pioglitazone, are not likely to have clinically relevant interactions with nirmatrelvir/ritonavir, but because individuals with diabetes and COVID-19 should follow "sick day rules," the patient should be advised to suspend metformin.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.