Fast Five Quiz: Monkeypox

Bret A. Nicks, MD


October 03, 2022

The 2022 outbreak has produced atypical symptoms when compared with previous monkeypox outbreaks. These symptoms include:

  • Lesions mostly confined to the genital and perianal areas, presenting with anal pain and bleeding

  • Scant or even single lesions, or even the complete absence of skin lesions

  • Lack of prodromal symptoms such as fever, myalgias, fatigue, and headache before the appearance of a rash

According to the largest international monkeypox case series to date, anogenital lesions, single genital ulcers, and mouth sores are all unique symptoms of the current monkeypox outbreak. Painful lesions, fever, swollen lymph nodes, and rash have been commonly associated with previous monkeypox outbreaks. The number of lesions continues to widely vary. Patients who are immunocompromised also widely vary in their presentations.

Learn more about monkeypox presentation.