If provided enough time, all patients with metastatic disease become resistant to androgen ablation.
After a rise in PSA level > 4 ng/dL, the median time to symptomatic progression is 6-8 months, according to Terris and colleagues. Further, median time to death after a PSA rise is 12-18 months. Survival is < 1 year once the patient exhibits symptoms, per the same authors.
Learn more about the management of metastatic CRPC.
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Cite this: Evelyn S. Marienberg. Fast Five Quiz: Castration-Resistant Metastatic and Advanced Prostate Cancer Management - Medscape - Nov 08, 2022.