Fast Five Quiz: Dry Eye Disease (Keratoconjunctivitis Sicca) Etiology and Pathophysiology

According to Chiang and colleagues, primary lacrimal gland deficiencies in non–SS-related aqueous-deficient dry eye that may impair aqueous production include:

• Idiopathic

• Age-related dry eye

• Congenital alacrima (eg, Riley-Day syndrome)

• Familial dysautonomia

The underlying cause of primary SS aqueous-deficient dry eye is unknown.

Secondary SS may be associated with:

• Rheumatoid arthritis

• Systemic lupus erythematosus

• Progressive systemic sclerosis (scleroderma)

• Psoriatic arthritis

• Primary biliary cirrhosis

• Interstitial nephritis

• Polymyositis

• Dermatomyositis

• Granulomatosis with polyangiitis (formerly Wegener granulomatosis)

• Polyarteritis nodosa

• Hashimoto thyroiditis

• Lymphocytic interstitial pneumonitis

• Idiopathic thrombocytopenic purpura

• Hypergammaglobulinemia

• Waldenström macroglobulinemia

Learn more about the etiology of aqueous-deficient dry eye.

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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: Christina R. Prescott. Fast Five Quiz: Dry Eye Disease (Keratoconjunctivitis Sicca) Etiology and Pathophysiology - Medscape - Nov 10, 2022.