Fast Five Quiz: Mantle Cell Lymphoma Workup

Ann S. LaCasce, MD, MMSc


February 08, 2023

Both the National Comprehensive Cancer Network (NCCN) and European Society for Medical Oncology (ESMO) guidelines recognize physical exam as an important component of the workup for MCL. It should include assessment of all node-bearing areas including Waldeyer's ring as well as peripheral nodes because the majority of patients present with lymphadenopathy (75%). Evaluation of the spleen and liver is recommended because splenomegaly and hepatomegaly (30% of patients) are common findings. While palpable masses in skin, breast, and salivary glands can be present, they are typically uncommon, according to Abbasi and colleagues.

In addition, the NCCN guidelines recommend the evaluation of performance status as part of the initial workup. Evaluation of B symptoms such as fever, night sweats, and weight loss should be included as well, per the same guidelines.

Learn more about MCL.


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