MCL is typically associated with a chromosome translocation between chromosome 11 and 14, t(11;14). According to NCCN guidelines, FISH or karyotyping for t(11;14) may be useful and can be used to confirm MCL and prevent misdiagnosis. Further, FISH testing is specifically recommended in ESMO guidelines.
LDH is included in the routine workup, and elevated LDH levels are indicative of a higher tumor burden. While elevated beta-2 microglobulin is associated with a worse prognosis, it is not considered to be an essential component of the workup in either the NCCN or ESMO guidelines.
Hepatitis B testing is recommended by the NCCN and the ESMO guidelines for patients if immunotherapy is under consideration owing to the risk for reactivation.
Learn more about MCL.
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Cite this: Ann S. LaCasce. Fast Five Quiz: Mantle Cell Lymphoma Workup - Medscape - Feb 08, 2023.