According to guidelines from the European Society for Medical Oncology, histology alone is insufficient to establish a diagnosis of MCL. Diagnosis of MCL is established by the histologic examination in combination with an IHC profile consisting of CD5+, CD10-/+, CD 23-/+, CD43+, and cyclin D1+. Notably, overexpression of cyclin D1 is a hallmark of MCL, and instances of cyclin D1- MCL are infrequent (< 5% of cases), per the National Comprehensive Cancer Network (NCCN).
FISH testing may also be useful, because translocation t(11;14) (q13; q32) is found 90% of MCL cases.
An excisional or incisional lymph node biopsy is standard of care, according to NCCN guidelines. While not optimal, the same guidelines state that core needle biopsy in conjunction with other assessments may be used in cases where lymph nodes are not accessible.
Learn more about MCL.
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Cite this: Ann S. LaCasce. Fast Five Quiz: Non-Hodgkin's Lymphoma: Mantle Cell Lymphoma Practice Essentials - Medscape - May 22, 2023.