Fast Five Quiz: Non-Hodgkin's Lymphoma: Mantle Cell Lymphoma Practice Essentials

Ann S. LaCasce, MD, MMSc


May 22, 2023

Approximately 10%-20% of patients with MCL present with an indolent form of the disease, including those with smoldering or asymptomatic non-nodal disease. Patients with this variant do not exhibit high-risk clinical or biologic features and often present with circulating disease, marrow involvement, and splenomegaly. SOX-11 is typically negative in this variant. Some patients survive > 7-10 years, and immediate treatment with systemic therapy may not be needed; a "watch and wait" strategy may be an option. Patients with non-nodal disease can acquire TP53 mutations, manifested by rapid progression of disease.

Learn more about MCL.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.