Fast Five Quiz: Signs and Symptoms of Mantle Cell Lymphoma

Ann S. LaCasce, MD, MMSc


February 07, 2023

Indolent MCL is an uncommon presentation of MCL, and the majority of cases with nodal disease express SOX-11, as is true in all subtypes of MCL. Patients who present, however, with leukemic disease and splenomegaly without nodal disease are typically SOX11-negative and usually immunoglobulin heavy chain variable mutated.

Peripheral blood, bone marrow, and spleen involvement are common, and patients present with a low tumor burden a Ki-67 proliferation fraction < 10%. However, in some cases, patients may present with gastrointestinal or blood/bone marrow involvement only, which may express SOX11 and have an indolent course.

Learn more about MCL.


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