The Ann Arbor classification system is used for staging and is on the basis of lymph node involvement and the presence of extrahepatic sites.
The majority of patients (nearly 70%-80%) with MCL present with stage III or IV disease with extensive lymph node involvement. Presentation with earlier stage disease is uncommon. Patients with stage I/II disease have a limited number of lymph nodes or extranodal sites involved. Laboratory values are critical in workup but are not a component of staging.
Learn more about MCL.
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Cite this: Ann S. LaCasce. Fast Five Quiz: Signs and Symptoms of Mantle Cell Lymphoma - Medscape - Feb 07, 2023.