Skill Checkup: A 62-Year-Old Man With Lumps on His Neck and Under His Arm

Ann S. LaCasce, MD, MMSc


May 25, 2023

Ki-67 proliferation fraction of < 30% in lymph nodes is associated with a more favorable prognosis of MCL, per NCCN guidelines. Pleomorphic histology, TP53 mutation, and the presence of blastoid cells are all typically associated with a more aggressive disease course.

The patient has a Ki-67 proliferation fraction of > 30% and has SOX11 negative, classical TP53 wild-type disease with small cells on morphology.


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