Rapid Review Quiz: Artificial Sweeteners

Romesh Khardori, MD, PhD


November 14, 2022

A recent randomized controlled trial observed the effects of nonnutritive sweetener (NNS) consumption among 120 healthy adults. All participants strictly avoided NNS before the study. Some remained NNS-free during the trial, whereas others used aspartame, saccharin, stevia, or sucralose daily for 2 weeks. The participants consumed NNS in amounts lower than the acceptable daily intake compared with controls receiving a packet of vehicle glucose or no supplement.

Each NNS "significantly and distinctly" altered stool and oral microbiome. Saccharin and sucralose significantly impaired glucose tolerance. The researchers note that these sweeteners' effects are likely to vary from person to person because of the uniqueness of individual microbiome-dependent glycemic tolerances.

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