Depression is common in patients with MS even in early stages of the disease. While a multifactorial etiology has been theorized for depression and depressive symptoms in patients with MS, a review by Masuccio and colleagues published in 2021 suggests that depression itself may be a symptom with a neurobiological basis rather than the consequence of the disability derived from the neurologic impairment associated with MS.
Cognitive impairment, such as difficulties in processing speed, attention, learning, memory, and executive functioning, has been shown to affect up to 70% of patients with MS. Although more severe cognitive impairment is seen in secondary progressive MS (SPMS), signs of cognitive involvement can be present early in the disease course.
Learn more about the clinical presentation of MS.
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Cite this: Christopher Luzzio. Fast Five Quiz: Multiple Sclerosis Diagnosis and Workup - Medscape - Nov 22, 2022.