According to 2021 consensus recommendations from the Magnetic Resonance Imaging in Multiple Sclerosis network, the Consortium of Multiple Sclerosis Centers, and the North American Imaging in MS Cooperative, a brain MRI with gadolinium is recommended for the diagnosis of MS. If the brain MRI is nondiagnostic or if the presenting symptoms are at the level of the spinal cord, a spinal cord MRI is recommended.
Lumbar puncture with CSF analysis is no longer routinely used in the investigation of MS; however, it may be useful when MRI is unobtainable, or MRI findings are nondiagnostic. In such cases, CSF is evaluated for OCBs and intrathecal immunoglobulin G production, as well as for signs of infection.
Learn more about imaging studies in the diagnosis and workup for MS.
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Cite this: Christopher Luzzio. Fast Five Quiz: Multiple Sclerosis Diagnosis and Workup - Medscape - Nov 22, 2022.