According to the CDC, acyclovir, famciclovir, and valacyclovir can treat genital herpes. However, valacyclovir 1 g (the valine ester of acyclovir) has enhanced absorption after oral administration, requiring two doses per day for 7-10 days. Famciclovir 250 mg also has high oral bioavailability but requires oral doses three times per day for 7-10 days, as does acyclovir 400 mg. Acyclovir 200 mg can be used, but it must be taken orally five times per day and is not recommended because of the frequency of dosing.
Learn more about valacyclovir.
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Cite this: Mary L. Windle. Rapid Rx Quiz: Sexually Transmitted Infection Drug Treatments - Medscape - Nov 18, 2022.